As the versatile synthetic sealant, surgeons rely on COSEAL Surgical Sealant as the only surgical sealant clinically proven to deliver both sealing and post surgical adhesion prevention efficacy.1,2
See Indications
Image of Coseal in applicator

Image of a sutured aortic valve sealed with Coseal

3-in-1 Solution for Sealing and Adhesion Prevention

COSEAL is clinically proven to provide a rapid seal at vascular suture lines, as well as reduce air leaks occurring after lung resection as compared to standard surgical technique.1,2,3  Additionally, COSEAL reduces the severity of postoperative cardiac adhesions.4

Mechanism of Action

COSEAL is composed of two synthetic biocompatible polyethylene glycol polymers that that rapidly crosslink with proteins in tissue and mechanically adhere to synthetic graft material. Learn more about how COSEAL works.

Additional Product Benefits

Flexible and Easy to Use


The translucent, motion-responsive material supports natural vascular dilation as well as  conforms to the anatomy of the expanding and contracting lung.6


Independent of the Coagulation Cascade

COSEAL works independent of the coagulation cascade, forming a direct mechanical barrier to blood flow regardless of the patient’s coagulation status.2,4

Cost Savings and Fewer Complications

In a retrospective study of 102 aortic Bentall procedures, using COSEAL as a suture line reinforcement contributed to fewer complications with significant cost savings when compared to not using COSEAL.5

COSEAL is indicated for:

  • Sealing suture lines along arterial and venous reconstructions
  • Enforcement of suture and staple lines in lung resection procedures
  • Patients undergoing cardiac surgery to prevent or reduce the incidence, severity and extent of post surgical adhesion formation
  • Patients undergoing laparotomy or laparoscopic abdomino-pelvic surgery as an adjunct to good surgical technique intended to reduce the incidence, severity and extent of post surgical adhesion formation

Do not use COSEAL as a bronchial stump sealant, during bronchial sleeve resections, or for sealing decorticated lung areas.
Do not use COSEAL in procedures in which pleural adhesions are desired.

COSEAL swells up to four times its volume within 24 hours of application and additional swelling occurs as the gel resorbs. Therefore surgeons should consider the maximum swell volume and its possible effect on surrounding anantomic structures potentially sensitive to compression

Rx only: For safe and proper use of this device, please refer to full device Instructions for Use.